Description

4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Quinoline is a high-value, advanced pharmaceutical intermediate and building block for organic synthesis. This compound is a key reagent in modern cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries for the development of new active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A critical boron-containing reagent for forming carbon-carbon bonds between aryl or heteroaryl groups, essential in medicinal chemistry.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, particularly those containing the quinoline scaffold with therapeutic applications.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the functionalized quinoline structure can impart specific biological activity.
• Materials Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, due to its electron-transporting quinoline core and boronic ester handle.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing complex ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target identification.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Quinoline
CAS No.	1035458-54-8
Molecular Formula	C₁₅H₂₀BNO₂
Molecular Weight	257.14 g/mol
Synonyms	4-Quinolineboronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline; Quinolin-4-ylboronic acid pinacol ester; 4-(Pinacolatoboryl)quinoline; 4-Quinolylboronic acid pinacol ester; 1035458-54-8; 4-Quinolineboronic Acid, Pinacol Ester
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Quinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your R&D and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.