Description

3-Hydroxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate. Its core value proposition lies in enabling precise carbon-carbon bond formation, which is essential for constructing complex molecular architectures in advanced research and development. This compound is particularly needed by pharmaceutical, agrochemical, and advanced materials chemists for applications in Suzuki-Miyaura cross-coupling reactions and as a versatile building block for heterocyclic synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a precursor for organic electronic materials, including polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Employed as a molecular probe or linker due to the reactivity of the boronic ester and nitrile functional groups.
• Ligand Synthesis: Useful for creating novel bidentate or tridentate ligands for catalysis and metal-organic frameworks (MOFs).
• Academic & Contract Research: A versatile reagent for methodological development in organic synthesis and cross-coupling catalysis studies.

Basic Information

Item	Details
Product Name	3-Hydroxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	1035266-34-2
Molecular Formula	C13H16BNO3
Molecular Weight	245.09 g/mol
Synonyms	5-Cyano-3-hydroxyphenylboronic acid pinacol ester; (3-Cyano-5-hydroxyphenyl)boronic acid pinacol ester; 3-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-hydroxybenzonitrile; 3-Hydroxy-5-borono benzonitrile pinacol ester; PINACOL 3-HYDROXY-5-CYANOPHENYLBORONATE; CAS 1035266-34-2
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance for sensitive coupling reactions. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.