Description

n-Boc-Isoindoline-4-Boronic Acid, Pinacol Ester is a high-purity, protected boronic acid ester building block essential for modern synthetic chemistry. This compound is a critical intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily used by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel chemical entities via cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing the isoindoline scaffold.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boron reagent for forming carbon-carbon bonds, enabling the construction of complex biaryl and heterobiaryl structures.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and for the parallel synthesis of novel compounds to explore structure-activity relationships (SAR).
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for commercial manufacturing.
• Agrochemical Research: Intermediate in the creation of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Potential precursor for organic electronic materials, such as those used in OLEDs and organic photovoltaics.

Basic Information

Product Name	n-Boc-Isoindoline-4-Boronic Acid, Pinacol Ester
CAS No.	1035235-28-9
Molecular Formula	C19H28BNO4
Molecular Weight	345.24 g/mol
Synonyms	tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-isoindole-2-carboxylate; 1,1-Dimethylethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydro-2H-isoindole-2-carboxylate; 2-Boc-1,2,3,4-tetrahydroisoquinoline-7-boronic acid pinacol ester; Boc-Isoindoline-4-Boronic Acid Pinacol Ester; N-Boc-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoindoline
EINECS	Contact for details

Quality Control

Our n-Boc-Isoindoline-4-Boronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.