Description

4-Methyl-2-Phenyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Oxazole CAS NO 1034566-03-4 is a high-value, multi-functional heterocyclic building block containing a pinacol boronate ester group. This compound is essential for modern synthetic chemistry, enabling efficient carbon-carbon bond formation via cross-coupling reactions. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-couplings for synthesizing complex drug candidates, particularly those containing oxazole and biaryl motifs.
• Agrochemical Synthesis: Used to construct novel active ingredients for crop protection agents, leveraging its boronate functionality for structural diversification.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLEDs and organic semiconductors, where the oxazole ring contributes to electron-transport properties.
• Chemical Biology & Probe Development: Employed in the synthesis of fluorescent tags and molecular probes for studying biological processes.
• Catalyst Ligand Synthesis: Utilized as a starting material for preparing sophisticated ligand systems used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CROs and CDMOs specializing in bespoke organic molecule production for client R&D pipelines.

Basic Information

Item	Details
Product Name	4-Methyl-2-Phenyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Oxazole
CAS No.	1034566-03-4
Molecular Formula	C16H20BNO3
Molecular Weight	285.15 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-2-phenyloxazole; 2-Phenyl-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxazole; 4-Methyl-2-phenyloxazole-5-boronic acid pinacol ester; Oxazole boronic ester; Pinacol (4-methyl-2-phenyloxazol-5-yl)boronate; 1034566-03-4; B-(4-Methyl-2-phenyl-5-oxazolyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-Methyl-2-Phenyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Oxazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.