Description

1-Bromo-2-Fluoro-3-(Trifluoromethoxy)Benzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and trifluoromethoxy substituents, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, and specific optical properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and creating compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	1-Bromo-2-Fluoro-3-(Trifluoromethoxy)Benzene
CAS No.	1033202-63-9
Molecular Formula	C7H3BrF4O
Molecular Weight	259.00 g/mol
Synonyms	2-Bromo-1-Fluoro-3-(Trifluoromethoxy)Benzene; 3-Bromo-2-Fluoroanisole, 1,1,1-Trifluoro Deriv.; Benzene, 1-bromo-2-fluoro-3-(trifluoromethoxy)-; 1-Bromo-2-fluoro-3-(trifluoromethoxy)benzene; 2-Fluoro-3-(trifluoromethoxy)bromobenzene; 3-(Trifluoromethoxy)-2-fluorobromobenzene
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-2-Fluoro-3-(Trifluoromethoxy)Benzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by GC, HPLC, and NMR is supplied with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.