Description

1-Bromo-2-Fluoro-4-(Methylsulfonyl)Benzene is a high-value, multi-functional aromatic building block characterized by its bromo, fluoro, and methylsulfonyl substituents. This compound is essential for advanced organic synthesis, enabling the precise construction of complex molecules through selective cross-coupling and substitution reactions. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science: Serves as a precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing sulfone group.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create biaryl and complex aromatic structures.
• Fluorinated Compound Library Synthesis: Critical for medicinal chemistry programs focused on building diverse screening libraries containing fluorinated arenes.
• Chemical Biology Probes: Used to create tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	1-Bromo-2-Fluoro-4-(Methylsulfonyl)Benzene
CAS No.	1032825-02-7
Molecular Formula	C7H6BrFO2S
Molecular Weight	253.09 g/mol
Synonyms	2-Fluoro-4-(methylsulfonyl)bromobenzene; 4-Bromo-3-fluoro-1-(methylsulfonyl)benzene; 1-Bromo-2-fluoro-4-(methanesulfonyl)benzene; 2-Fluoro-4-methanesulfonylbromobenzene; Benzene, 1-bromo-2-fluoro-4-(methylsulfonyl)-; 1032825-02-7; 4-(Methylsulfonyl)-2-fluorobromobenzene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is analyzed to confirm identity, purity, and impurity profile. Certificates of Analysis (COA) detailing lot-specific results from HPLC, GC, NMR, and other analytical techniques are available upon request. We adhere to cGMP principles for production and quality management where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.