Description

6-(tert-Butyloxycarbonyl-Methylamino)Pyridine-3-Boronic Acid Pinacol Ester is a high-value, protected boronic acid ester building block used in advanced organic synthesis. This compound matters because it provides a stable, reactive handle for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. It is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing new active ingredients, particularly for creating biaryl and heterobiaryl structures. The CAS number for this compound is provided in the table below.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific biaryl motifs.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysts, and advanced polymers via cross-coupling methodologies.
• Chemical Biology & Proteolysis-Targeting Chimeras (PROTACs): Serves as a versatile linker component in the design of bifunctional molecules for targeted protein degradation.
• Academic & R&D Laboratories: A critical reagent for methodological development in synthetic organic chemistry and for constructing complex molecular libraries for screening.

Basic Information

Product Name	6-(tert-Butyloxycarbonyl-Methylamino)Pyridine-3-Boronic Acid Pinacol Ester
CAS No.	1032758-87-4
Molecular Formula	C₁₈H₂₉BN₂O₄
Molecular Weight	348.25 g/mol
Synonyms	Boc-Protected 6-(Methylamino)Pyridine-3-Boronic Acid Pinacol Ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-[(2-methylpropan-2-yl)oxycarbonyl(methyl)amino]pyridine; 6-[(tert-Butoxycarbonyl)(methyl)amino]pyridine-3-boronic acid pinacol ester; 5-[(tert-Butoxycarbonyl)(methyl)amino]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; N-Boc-N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
EINECS	Contact for details

Quality Control

Every batch of 6-(tert-Butyloxycarbonyl-Methylamino)Pyridine-3-Boronic Acid Pinacol Ester is produced and tested under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to ensure compliance with your research and development specifications. Our commitment to reliable supply and consistent quality supports critical pharmaceutical and fine chemical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label/Certificate of Analysis. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.