Description

tert-Butyl 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclobutylcarbamate is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester group, a critical functional handle for modern synthetic transformations. This compound is essential for facilitating efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of contemporary medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those requiring the incorporation of a biaryl moiety.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester partner for coupling with aryl or vinyl halides to construct biaryl and styrenyl structures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Employed in the scale-up and route scouting for the commercial manufacturing of target molecules.
• Agrochemical Synthesis: Potential intermediate in the creation of novel herbicides or fungicides with complex aromatic backbones.
• Material Science Precursor: Can be used in the synthesis of organic electronic materials, such as polymers or small molecules for OLEDs.

Basic Information

Product Name	tert-Butyl 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclobutylcarbamate
CAS No.	1032528-06-5
Molecular Formula	C21H32BNO4
Molecular Weight	373.30 g/mol
Synonyms	1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutyl carbamic acid tert-butyl ester; tert-Butyl N-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl]carbamate; 1-(4-(Pinacolatoboron)phenyl)cyclobutanamine, N-BOC-protected; BOC-1-(4-Bpin-phenyl)cyclobutylamine; tert-Butyl (1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutyl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclobutylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent hydrolysis of the boronate ester.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.