Description

Oxirane,2-(Chloromethyl-D2)-,(2R) CAS NO 1032237-24-3 is a chiral, deuterated epoxide derivative, specifically the (R)-enantiomer of epichlorohydrin-d2, serving as a critical building block for introducing stereochemistry and isotopic labels into complex molecules. Its primary value lies in enabling advanced research and development in pharmaceutical chemistry, where it is used to create deuterated drug candidates with potentially improved metabolic profiles and as a chiral synthon for stereoselective synthesis. This high-purity intermediate is essential for scientists and process chemists in pharmaceutical R&D, agrochemical development, and specialized fine chemical manufacturing who require precise control over molecular structure and isotopic composition.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of deuterated active pharmaceutical ingredients (APIs) and prodrugs.
• Metabolic Stability Studies: Used to incorporate deuterium atoms into lead compounds to study and potentially improve their pharmacokinetic properties.
• Asymmetric Synthesis: Employed as a chiral electrophile in nucleophilic ring-opening reactions to construct enantiomerically pure compounds.
• Agrochemical Research: Intermediate in the development of novel, labeled pesticides and herbicides for mode-of-action and environmental fate studies.
• Material Science Precursor: Used in the synthesis of specialized polymers and resins where deuterium labeling or specific chirality is required for property analysis.
• Bioconjugation & Probe Development: Serves as a reactive handle for attaching labels or functional groups to biomolecules in a stereocontrolled manner.
• Reference Standard: Acts as an analytical standard for quality control and method development in chiral and isotopic analysis.

Basic Information

Product Name	Oxirane,2-(Chloromethyl-D2)-,(2R)
CAS No.	1032237-24-3
Molecular Formula	C3H3D2ClO
Molecular Weight	96.53 g/mol
Synonyms	(R)-(-)-Epichlorohydrin-d2; (2R)-2-[(Chloromethyl-d2)oxirane]; (R)-1-Chloro-2,3-epoxypropane-1,1-d2; (R)-Epichlorohydrin-d2; (R)-ECH-d2; (2R)-Epichlorohydrin-d2; (R)-3-Chloro-1,2-epoxypropane-1,1-d2; Deuterated (R)-Epichlorohydrin
EINECS	Contact for details

Quality Control

This high-value chiral intermediate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and isotopic purity. Product identity, chiral purity (enantiomeric excess), and chemical purity are verified using advanced analytical techniques including chiral GC/HPLC, NMR (1H, 13C, 2H), and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, isotopic enrichment, and impurity profile is provided with each batch to support your critical R&D and cGMP development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere to maintain stability and purity. Keep away from strong bases, acids, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral GC/HPLC)	≥ 99.0% ee
Deuterium Enrichment (MS/NMR)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.