Description

n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropanecarboxamide is a high-value, advanced pharmaceutical intermediate featuring a cyclopropane carboxamide moiety linked to a pinacol boronate ester. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules through versatile cross-coupling reactions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) drug candidates.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key boronic ester reagent for constructing biaryl and heterobiaryl structures in drug discovery pipelines.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel therapeutic compounds, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed in the synthesis of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Facilitates the creation of labeled molecules for studying biological pathways and target engagement.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with novel modes of action.

Basic Information

Product Name	n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropanecarboxamide
CAS No.	1031747-45-1
Molecular Formula	C16H22BNO3
Molecular Weight	287.17 g/mol
Synonyms	4-(Cyclopropanecarboxamido)phenylboronic acid pinacol ester; 4-Cyclopropanecarboxamidophenylboronic acid pinacol ester; Cyclopropanecarboxamide, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; N-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxamide; 1031747-45-1; AKOS025311064; BCP32613; CS-0415371.
EINECS	Contact for details

Quality Control

Our n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropanecarboxamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.