Description

n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarboxamide is a high-purity, advanced pharmaceutical intermediate featuring a cyclopropane carboxamide moiety linked to a pinacol boronate ester. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules through versatile cross-coupling reactions. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients, particularly in the areas of kinase inhibitors and other small-molecule therapeutics.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester reagent for constructing biaryl and heterobiaryl scaffolds in drug discovery.
• Pharmaceutical Intermediate: Used in the research and development of novel active pharmaceutical ingredients (APIs), especially targeted therapies.
• Agrochemical Synthesis: Employed as a building block for creating new crop protection agents and herbicides.
• Material Science Research: Utilized in the synthesis of organic electronic materials and ligands for catalysis.
• Chemical Biology Probes: Acts as a precursor for developing molecular probes and tools for biological target identification.
• Process Chemistry & Scale-up: Suitable for optimization and kilogram-scale production under GMP-like conditions for clinical trial material.

Basic Information

Product Name	n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarboxamide
CAS No.	1031747-40-6
Molecular Formula	C₁₆H₂₂BNO₃
Molecular Weight	287.17 g/mol
Synonyms	3-(Cyclopropanecarboxamido)phenylboronic acid pinacol ester; N-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarboxamide; 3-Cyclopropanecarboxamidophenylboronic acid pinacol ester; Cyclopropanecarboxylic acid [3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-amide; B-[3-(Cyclopropanecarbonylamino)phenyl]boronic acid pinacol ester; 1031747-40-6; 3-Aminophenylboronic acid pinacol ester cyclopropanecarboxamide derivative.
EINECS	Contact for details

Quality Control

Our n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with the standards required for pharmaceutical R&D and cGMP intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.