Description

n-Ethyl-N'-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyridinyl]-Urea is a high-value, organoboron-containing chemical building block designed for advanced synthetic applications. Its core value lies in the protected boronic ester functional group, which is crucial for modern cross-coupling reactions like Suzuki-Miyaura, enabling the efficient construction of complex molecular architectures. This compound is primarily needed by pharmaceutical R&D and agrochemical discovery teams for synthesizing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing pyridine and urea motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Used in palladium-catalyzed reactions to form carbon-carbon bonds, essential for constructing complex heterocyclic and biaryl structures in medicinal chemistry.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science Precursor: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and sensors, where precise molecular structure is critical.
• Chemical Biology Probe Synthesis: Used to create tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring specialized boronic ester chemistry.

Basic Information

Item	Details
Product Name	n-Ethyl-N'-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyridinyl]-Urea
CAS No.	1031431-96-5
Molecular Formula	C16H26BN3O3
Molecular Weight	319.21 g/mol
Synonyms	1-Ethyl-3-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]urea; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[(ethylamino)carbonylamino]pyridine; Urea, N-ethyl-N'-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-; 2-Pyridinylurea boronic ester derivative; 5-Pinacolboryl-2-[(ethylcarbamoyl)amino]pyridine
EINECS	Contact for details

Quality Control

Our n-Ethyl-N'-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyridinyl]-Urea is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting standards for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.