Description

4-Chloro-2-Methylphenylboronic Acid Pinacol Ester is a protected boronic acid derivative, a crucial intermediate in modern synthetic organic chemistry. Its primary value lies in its enhanced stability and handling properties compared to the free boronic acid, making it indispensable for complex cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key organoboron reagent for forming carbon-carbon bonds, widely used in synthesizing biaryl structures found in active pharmaceutical ingredients (APIs) and liquid crystal materials.
• Pharmaceutical Intermediate: Serves as a critical building block in the research and development of novel drug candidates, particularly those containing substituted biphenyl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require specific chlorinated and methylated aromatic systems.
• Material Science Research: Employed in the synthesis of organic semiconductors, ligands for catalysts, and novel polymers with tailored electronic properties.
• Chemical Library Development: A valuable reagent for medicinal chemistry and high-throughput screening libraries aimed at discovering new bioactive molecules.

Basic Information

Product Name	4-Chloro-2-Methylphenylboronic Acid Pinacol Ester
CAS No.	1030832-75-7
Molecular Formula	C₁₃H₁₈BClO₂
Molecular Weight	252.54 g/mol
Synonyms	4-Chloro-2-methylbenzeneboronic acid pinacol ester; (4-Chloro-2-methylphenyl)boronic acid pinacol ester; 2-Methyl-4-chlorophenylboronic acid pinacol ester; B-(4-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(4-chloro-2-methylphenyl)-1,3,2-dioxaborolane; Pinacol (4-chloro-2-methylphenyl)boronate
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Methylphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use or when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.