Description

Dichloro[1,3-Bis(2,4,6-Trimethylphenyl)-2-Imidazolidinylidene]{[5-(2-Ethoxy-2-Oxoethanamido)]-2-Isopropoxybenzylidene}Ruthenium(II) is a highly specialized, third-generation Grubbs-Hoveyda type olefin metathesis catalyst. This compound matters for its exceptional thermal stability and functional group tolerance, enabling precise and efficient carbon-carbon double bond formation in complex molecular architectures. It is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel active ingredients and polymers.

Application

• Pharmaceutical Intermediate Synthesis: Key catalyst for ring-closing metathesis (RCM) and cross-metathesis (CM) in the production of complex, biologically active molecules and APIs.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring specific olefin architectures.
• Advanced Polymer & Material Science: Enables the synthesis of specialty polymers, dendrimers, and functionalized materials via ring-opening metathesis polymerization (ROMP) and acyclic diene metathesis (ADMET).
• Fine Chemical & Fragrance Manufacturing: Facilitates the construction of specific olefinic bonds in high-value flavor and fragrance compounds.
• Academic & Industrial R&D: An essential tool for methodological development in organic synthesis and catalysis research.
• Process Chemistry Optimization: Employed for scalable, efficient routes in pilot plants and commercial manufacturing due to its robustness.

Basic Information

Product Name	Dichloro[1,3-Bis(2,4,6-Trimethylphenyl)-2-Imidazolidinylidene]{[5-(2-Ethoxy-2-Oxoethanamido)]-2-Isopropoxybenzylidene}Ruthenium(II)
CAS No.	1030618-11-1
Molecular Formula	C41H49Cl2N3O4Ru
Molecular Weight	807.83 g/mol
Synonyms	Grubbs-Hoveyda Catalyst 2nd Generation, Modified; Hoveyda-Grubbs Catalyst 2nd Gen, Nitro-Substituted; [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro[[5-[[(2-ethoxy-2-oxoethyl)amino]carbonyl]-2-isopropoxyphenyl]methylene]ruthenium; Nitro-Grela Catalyst; Zhan Catalyst 1B; Ru-based Olefin Metathesis Catalyst; (2-Isopropoxy-5-(2-ethoxy-2-oxoacetamido)benzylidene) Complex
EINECS	Contact for details

Quality Control

Our high-purity catalyst is manufactured under controlled conditions to ensure batch-to-batch consistency and optimal catalytic performance. Each lot undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, freezer-safe environment. This material is moisture-sensitive and easily oxidized; prolonged exposure to air, light, or ambient temperature will degrade catalytic activity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Dark green to brown crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Elemental Analysis (C, H, N)	Within theoretical ± 0.4%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.