Description

(R)-3-Methyl-1-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Butan-1-Amine Hydrochloride is a high-purity, chiral boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in enabling the precise construction of complex molecules through efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require enantiomerically pure intermediates for developing active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds in complex molecule assembly, prized for its functional group tolerance and mild reaction conditions.
• Agrochemical Synthesis: Used in the research and production of advanced, chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Material Science Research: Serves as a precursor for novel organic electronic materials and liquid crystals where precise molecular architecture is needed.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric transformations to introduce chiral centers with high enantiomeric excess.
• Process Chemistry & Scale-Up: Provides a reliable and scalable intermediate for transitioning from laboratory-scale discovery to commercial manufacturing processes.

Basic Information

Product Name	(R)-3-Methyl-1-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Butan-1-Amine Hydrochloride
CAS No.	1029701-30-1
Molecular Formula	C11H25BClNO2
Molecular Weight	249.59 g/mol
Synonyms	(R)-1-Amino-3-methylbutylboronic acid pinacol ester hydrochloride; (R)-3-Methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butylamine hydrochloride; (R)-Valine-derived MIDA boronate hydrochloride (analogous class); (R)-1-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylbutan-1-amine hydrochloride; (R)-Pinacol (3-methyl-1-aminobutyl)boronate hydrochloride; (R)-B-((3-Methylbutyl)amino)pinacolborane hydrochloride; (R)-tert-Leucine boronic ester derivative hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-3-Methyl-1-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Butan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, NMR (1H, 11B, 13C), and mass spectrometry, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.