Description

2-Chloro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Imidazole-5-Boronic Acid Pinacol Ester is a sophisticated boronic ester derivative, a key protected intermediate in modern synthetic organic chemistry. Its primary value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and advanced materials. The CAS number for this product is 1029684-36-3.

Application

This high-value boronic ester is a versatile building block designed for advanced chemical synthesis. Its primary and related applications include:

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug candidates, particularly those containing imidazole or heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its ability to form carbon-carbon bonds under mild conditions.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysis, and novel polymers.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air- and moisture-tolerant boronate reagent for palladium-catalyzed aryl-aryl bond formation.
• Medicinal Chemistry Library Construction: Facilitates the rapid parallel synthesis of diverse compound libraries for high-throughput screening.
• Process Chemistry & Scale-Up: The THP-protecting group offers advantageous handling and purification properties for large-scale manufacturing processes.

Basic Information

Product Name	2-Chloro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Imidazole-5-Boronic Acid Pinacol Ester
CAS No.	1029684-36-3
Molecular Formula	C14H20BClN2O3
Molecular Weight	310.58 g/mol
Synonyms	2-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-imidazole-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-imidazole; 2-Chloro-1-(tetrahydropyran-2-yl)-1H-imidazole-5-boronic acid pinacol ester; 2-Chloro-1-(THP)-1H-imidazole-5-boronic acid pinacol ester; 5-Borono-2-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-imidazole pinacol ester; 2-Chloro-1-(2-tetrahydropyranyl)-1H-imidazole-5-boronic acid pinacol ester; CAS 1029684-36-3
EINECS	Contact for details

Quality Control

We supply 2-Chloro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Imidazole-5-Boronic Acid Pinacol Ester in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles to support your regulatory and process needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.