Description

2-Fluoropyrimidine-5-Boronic Acid is a high-value boronic acid derivative and a key synthetic building block in modern organic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated pyrimidine-based compounds with potential therapeutic applications.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides by introducing the fluoropyrimidine moiety into lead structures.
• Material Science: Serves as a building block for constructing organic electronic materials, such as ligands for OLEDs and other functional polymers.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries via parallel synthesis for high-throughput screening.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring specific, complex fluorinated heterocycles.

Basic Information

Product Name	2-Fluoropyrimidine-5-Boronic Acid
CAS No.	1029654-42-9
Molecular Formula	C4H4BFN2O2
Molecular Weight	141.90 g/mol
Synonyms	(2-Fluoropyrimidin-5-yl)boronic acid; 5-Borono-2-fluoropyrimidine; 2-Fluoro-5-pyrimidineboronic acid; 2-Fluoropyrimidine-5-boronic acid pinacol ester (common derivative); 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoropyrimidine; 2-Fluoropyrimidin-5-ylboronic Acid
EINECS	Contact for details

Quality Control

Our 2-Fluoropyrimidine-5-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and potentially moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.