Description

5-Hydroxy-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and materials science research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and OLED materials industries seeking to construct complex molecular architectures efficiently.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its boronate functionality for structural diversification.
• Materials Science: Serves as a precursor in the creation of organic electronic materials, such as those used in organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs).
• Chemical Biology & Proteomics: Employed as a molecular probe or linker in bioconjugation chemistry and the development of activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: A vital reagent for methodology development and complex molecule synthesis in university and CRO (Contract Research Organization) laboratories.
• Liquid Crystal & Polymer Chemistry: Utilized to introduce functionalized aromatic units into polymers and liquid crystal molecules to modify their physical and electronic properties.

Basic Information

Product Name	5-Hydroxy-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	1029439-74-4
Molecular Formula	C₁₃H₁₆BNO₃
Molecular Weight	245.09 g/mol
Synonyms	2-Cyano-5-hydroxyphenylboronic acid pinacol ester; 5-Hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; (5-Cyano-2-hydroxyphenyl)boronic acid pinacol ester; 2-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; Pinacol (5-cyano-2-hydroxyphenyl)boronate; 5-Hydroxy-2-borono benzonitrile pinacol ester; CAS 1029439-74-4
EINECS	Contact for details

Quality Control

Every batch of 5-Hydroxy-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR (¹H and ¹³C), and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.