Description

3-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate. Its core value proposition lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and advanced materials synthesis. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl or phenolic motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require halogenated phenolic structures.
• Material Science Precursor: Serves as a monomer or functionalization agent in the production of advanced polymers, liquid crystals, and organic semiconductors.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes, enzyme inhibitors, and bioconjugation reagents leveraging the boronic acid/ester functionality.
• Cross-Coupling Reactions: A dedicated reagent for Suzuki-Miyaura cross-coupling to introduce the 3-chloro-4-hydroxyphenyl moiety into target molecules with high efficiency.
• Organic Synthesis Research: A versatile starting material in academic and industrial R&D for exploring new synthetic methodologies and constructing complex organic molecules.

Basic Information

Product Name	3-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol
CAS No.	1029439-70-0
Molecular Formula	C12H16BClO3
Molecular Weight	254.52 g/mol
Synonyms	2-(3-Chloro-4-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-chlorophenol; 3-Chloro-4-hydroxybenzeneboronic acid pinacol ester; (3-Chloro-4-hydroxyphenyl)boronic acid pinacol ester; Phenol, 3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.