Description

2-(2,4-Dichloro-6-(Ethoxymethoxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester intermediate essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides with specific activity profiles.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Scale-up Process Chemistry: A reliable intermediate for pilot plant and commercial-scale manufacturing of target molecules requiring this specific aryl boronate fragment.

Basic Information

Product Name	2-(2,4-Dichloro-6-(Ethoxymethoxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1028332-21-9
Molecular Formula	C₁₅H₂₁BCl₂O₄
Molecular Weight	359.04 g/mol
Synonyms	2,4-Dichloro-6-(ethoxymethoxy)phenylboronic acid pinacol ester; (2,4-Dichloro-6-(ethoxymethoxy)phenyl)boronic acid pinacol ester; 2,4-Dichloro-6-(ethoxymethoxy)benzeneboronic acid pinacol ester; Pinacol [2,4-dichloro-6-(ethoxymethoxy)phenyl]boronate; 2-(2,4-Dichloro-6-(Ethoxymethoxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane; CAS 1028332-21-9
EINECS	Contact for details

Quality Control

Our 2-(2,4-Dichloro-6-(Ethoxymethoxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive cross-coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.