Description

Sphos Pd G1, Methyl T-Butyl Ether Adduct is a highly active and versatile palladium-based catalyst precursor, specifically designed for Buchwald-Hartwig amination and other cross-coupling reactions. Its value lies in providing excellent catalytic performance with enhanced stability and handling characteristics compared to more sensitive phosphine-ligated palladium complexes. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable and efficient catalysts for constructing carbon-nitrogen and carbon-carbon bonds.

Application

• Pharmaceutical Intermediate Synthesis: Key catalyst for Buchwald-Hartwig amination in the production of active pharmaceutical ingredients (APIs) and complex drug candidates.
• Agrochemical Manufacturing: Enables the synthesis of novel herbicides, fungicides, and insecticides through efficient C-N and C-C bond-forming reactions.
• Material Science Research: Used in the development of organic electronic materials, such as OLEDs and conductive polymers, via cross-coupling methodologies.
• Academic & Industrial R&D: A preferred catalyst for method development and scale-up studies in organic synthesis due to its robust performance.
• Fine Chemical Production: Facilitates the synthesis of specialty chemicals, flavors, and fragrances requiring selective amination steps.

Basic Information

Product Name	Sphos Pd G1, Methyl T-Butyl Ether Adduct
CAS No.	1028206-58-7
Molecular Formula	C31H49O2P2Pd
Molecular Weight	629.07 g/mol
Synonyms	Palladium SPhos G1 Methyl tert-Butyl Ether Adduct; [2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl][2-(2-aminoethyl)phenyl]palladium(II) Methyl t-Butyl Ether Adduct; SPhos-Pd-G1 Methyl tert-Butyl Ether Adduct; Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) Methyl tert-Butyl Ether Adduct; SPhos Palladacycle Gen 1 MTBE Adduct; Pd-SPhos-G1 MTBE Adduct; CAS 1028206-58-7
EINECS	Contact for details

Quality Control

Our Sphos Pd G1, Methyl T-Butyl Ether Adduct is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic activity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and performance-related metrics. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical and fine chemical supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent decomposition. The product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers must be sealed immediately after use and kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (Pd content)	≥ 16.5%
Purity (HPLC)	≥ 95.0%
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.