Description

2-Chloro-3,5-Dibromobenzotrifluoride is a halogenated benzotrifluoride derivative, a versatile and high-value fluorinated aromatic building block prized for its unique electronic and steric properties. This compound is critical for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where the introduction of fluorine and halogen atoms can dramatically alter biological activity and material performance. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl and halogen groups enhance lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a core building block for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, improving charge transport and thermal stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart flame retardancy, chemical resistance, and altered refractive indices.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the presence of bromine atoms, enabling rapid diversification of chemical space.
• Organic Synthesis Reagent: Employed in nucleophilic aromatic substitution and as a precursor for generating other functionalized benzotrifluorides in custom synthesis projects.

Basic Information

Product Name	2-Chloro-3,5-Dibromobenzotrifluoride
CAS No.	1027512-27-1
Molecular Formula	C7H2Br2ClF3
Molecular Weight	352.35 g/mol
Synonyms	1-Chloro-2,4-dibromo-5-(trifluoromethyl)benzene; 2,4-Dibromo-1-chloro-5-(trifluoromethyl)benzene; 3,5-Dibromo-2-chlorobenzotrifluoride; Benzene, 1-chloro-2,4-dibromo-5-(trifluoromethyl)-; 2-Chloro-3,5-dibromo-α,α,α-trifluorotoluene
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3,5-Dibromobenzotrifluoride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profile by HPLC, GC, NMR, and IR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.