Description

2-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole is a high-value, heterocyclic boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its primary commercial value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to synthesize novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing benzoxazole scaffolds with therapeutic potential.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides by introducing the benzoxazole moiety into target molecules.
• Material Science Research: Building block for the development of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the creation of molecular probes and tags for studying biological processes and diagnostics.
• Academic & Industrial R&D: Fundamental reagent for method development and exploring new chemical spaces in organic synthesis laboratories worldwide.

Basic Information

Product Name	2-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole
CAS No.	1025719-20-3
Molecular Formula	C₁₆H₂₂BNO₃
Molecular Weight	287.16 g/mol
Synonyms	7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methylbenzoxazole; 2-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)benzoxazole; 2-Methylbenzoxazole-7-boronic acid pinacol ester; 7-(Pinacolatoboryl)-2-methylbenzoxazole; 2-Methyl-7-(pinacolboron)benzoxazole; Benzoxazole, 2-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1025719-20-3
EINECS	Contact for details

Quality Control

Our 2-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality management system is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.