Description

n-Boc-3-Formyl-5-Indoleboronic Acid Pinacol Ester is a high-purity, multi-functional boronic ester building block designed for advanced organic synthesis. This compound is critically important for facilitating efficient cross-coupling reactions, particularly in the construction of complex heterocyclic scaffolds. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel indole-based active pharmaceutical ingredients (APIs) and drug candidates via Suzuki-Miyaura cross-coupling.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate complex indole motifs for enhanced biological activity.
• Material Science: Serves as a building block for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Chemical Biology: Employed in the synthesis of molecular probes and bioconjugates for studying biological pathways and protein interactions.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry programs.
• Catalyst Ligand Synthesis: Used to prepare sophisticated ligands for transition metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	n-Boc-3-Formyl-5-Indoleboronic Acid Pinacol Ester
CAS No.	1025707-92-9
Molecular Formula	C20H26BNO5
Molecular Weight	371.24 g/mol
Synonyms	5-Formyl-1H-indole-3-boronic acid, 1-(1,1-dimethylethyl) ester, pinacol ester; 1-Boc-3-formyl-5-indoleboronic acid pinacol ester; tert-Butyl 3-formyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-3-carbaldehyde 1-Boc derivative; 1-(tert-Butoxycarbonyl)-3-formyl-5-indoleboronic acid pinacol ester; 3-Formyl-1-Boc-5-indoleboronic acid pinacol ester; 5-Borono-3-formyl-1H-indole-1-carboxylic acid tert-butyl ester pinacol cyclic ester.
EINECS	Contact for details

Quality Control

Our n-Boc-3-Formyl-5-Indoleboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive analytical data, including HPLC purity, NMR (1H, 13C, 11B), and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request for every lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. Keep the container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.