Description

2-tert-Butylisonicotinaldehyde is a specialized pyridine derivative aldehyde, serving as a crucial high-purity building block in advanced organic synthesis. Its value lies in the unique steric and electronic properties imparted by the tert-butyl group adjacent to the aldehyde functionality on the pyridine ring. This compound is primarily needed by research and development chemists and process scale-up teams within the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the pyridine core provides essential bioactivity.
• Ligand Precursor: Serves as a starting material for the preparation of sophisticated chelating ligands used in catalysis and material science.
• Functional Material Research: Employed in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its rigid, aromatic structure.
• Chemical Biology Probes: Utilized to create tagged molecules and probes for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Heck reactions, for carbon-carbon bond formation.

Basic Information

Product Name	2-tert-Butylisonicotinaldehyde
CAS No.	1023812-90-9
Molecular Formula	C10H13NO
Molecular Weight	163.22 g/mol
Synonyms	2-(tert-Butyl)isonicotinaldehyde; 4-Formyl-2-tert-butylpyridine; 2-tert-Butyl-4-formylpyridine; 2-(1,1-Dimethylethyl)-4-pyridinecarboxaldehyde; 4-Pyridinecarboxaldehyde, 2-(1,1-dimethylethyl)-; Isonicotinaldehyde, 2-tert-butyl-
EINECS	Contact for details

Quality Control

Every batch of 2-tert-Butylisonicotinaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and GC-MS, is supplied with each shipment to guarantee identity, purity, and consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, the container should be purged with inert gas after each opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.