Description

1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole-4-Carbaldehyde is a versatile and high-value heterocyclic building block, specifically an indazole derivative protected with a tetrahydropyranyl (THP) group. This compound matters as a critical synthetic intermediate in modern pharmaceutical research and development, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of small molecule drug candidates, particularly those targeting kinases and other enzymes.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Chemical Biology: Serves as a versatile scaffold for creating molecular probes and tool compounds to study biological pathways.
• Material Science: Potential building block for organic electronic materials and specialty polymers due to its conjugated indazole core.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific research projects and scale-up campaigns.
• Academic Research: Utilized in university and institutional labs for methodological development and exploratory chemistry.

Basic Information

Product Name	1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole-4-Carbaldehyde
CAS No.	1022158-36-6
Molecular Formula	C₁₃H₁₄N₂O₂
Molecular Weight	230.26 g/mol
Synonyms	1H-Indazole-4-carboxaldehyde, 1-(tetrahydro-2H-pyran-2-yl)-; 1-(Oxan-2-yl)-1H-indazole-4-carbaldehyde; 1-THP-indazole-4-carbaldehyde; 4-Formyl-1-(tetrahydropyran-2-yl)-1H-indazole; 1022158-36-6; 1-(Tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carboxaldehyde; 1-(2H-Tetrahydropyran-2-yl)-1H-indazole-4-carbaldehyde
EINECS	Contact for details

Quality Control

Our 1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole-4-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from heat, sparks, and open flame. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.