Description

3,3-Difluoro-2,2-Dimethylpropanoic Acid is a high-value fluorinated carboxylic acid building block. This compound is prized for its unique steric and electronic properties imparted by the gem-dimethyl and difluoromethylene groups, making it a critical intermediate in advanced synthesis. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating metabolically stable analogs and modulating physicochemical properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of protease inhibitors, kinase inhibitors, and other small molecule therapeutics where fluorine substitution is used to enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro moiety can improve biological activity and environmental persistence profiles.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Monomer: Potential monomer for creating specialty polymers with tailored surface properties, chemical resistance, and low dielectric constants for electronic applications.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial R&D exploring new C-F bond formation reactions and the synthesis of complex fluorinated molecules.

Basic Information

Product Name	3,3-Difluoro-2,2-Dimethylpropanoic Acid
CAS No.	1022154-50-2
Molecular Formula	C5H8F2O2
Molecular Weight	138.11 g/mol
Synonyms	3,3-Difluoro-2,2-dimethylpropionic Acid; 2,2-Dimethyl-3,3-difluoropropanoic Acid; α,α-Dimethyl-β,β-difluoropropionic Acid; DFDPA; 1022154-50-2; Propanoic acid, 3,3-difluoro-2,2-dimethyl-; 3,3-Difluoro-2,2-dimethylpropanoic acid
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-2,2-Dimethylpropanoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.