Description

5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-2-methoxypyridine (Saltdata: Free) is a high-purity, protected boronic ester derivative, a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient, selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop active pharmaceutical ingredients (APIs), novel crop protection agents, and organic electronic materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs), particularly those containing pyridine and methoxy-substituted aromatic systems.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides through structure-activity relationship (SAR) studies and lead optimization.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air- and moisture-tolerant boronic ester reagent for palladium-catalyzed carbon-carbon bond formation, crucial for constructing biaryl and heterobiaryl structures.
• Material Science: Employed in the synthesis of organic semiconductors, ligands for catalysts, and monomers for functional polymers.
• Chemical Biology & Proteomics: Can be utilized as a building block for creating molecular probes, enzyme inhibitors, or tags for bioconjugation strategies.
• Academic & Contract Research: A valuable reagent for methodology development and synthetic route exploration in academic laboratories and CROs (Contract Research Organizations).

Basic Information

Item	Details
Product Name	5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-2-methoxypyridine (Saltdata: Free)
CAS No.	1022094-44-5
Molecular Formula	C12H18BNO3
Molecular Weight	235.09 g/mol
Synonyms	2-Methoxy-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)pyridine; 5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-2-methoxypyridine; 2-Methoxypyridine-5-boronic acid, 5,5-dimethyl-1,3,2-dioxaborinane ester; 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine analog (protected form); Pinacol boronate ester analog; MIDA boronate alternative; Pyridine-5-boronic acid pinacol ester derivative.
EINECS	Contact for details

Quality Control

Our 5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-2-methoxypyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards required for GMP intermediates and research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient air during handling. Recommended storage temperature: 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.