Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole-1-Propanenitrile is a high-value, functionalized pyrazole boronic ester derivative that serves as a critical synthetic intermediate. Its core value lies in enabling efficient cross-coupling reactions, specifically Suzuki-Miyaura couplings, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of novel pesticides, herbicides, and fungicides by providing a versatile handle for structural diversification.
• Material Science: Employed in the creation of organic electronic materials, such as OLEDs and organic semiconductors, where its boronate group facilitates polymerization or functionalization.
• Chemical Biology & Proteomics: Acts as a valuable probe or linker in bioconjugation chemistry and the development of activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: Serves as a fundamental reagent in organic chemistry laboratories for method development and the synthesis of complex heterocyclic compounds.
• Ligand Synthesis: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole-1-Propanenitrile
CAS No.	1022092-33-6
Molecular Formula	C13H20BN3O2
Molecular Weight	261.13 g/mol
Synonyms	1H-Pyrazole-1-propanenitrile, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-propanenitrile; 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-propanenitrile; 4-Pinacolatoboryl-1H-pyrazole-1-propanenitrile; 4-Borono-1H-pyrazole-1-propanenitrile pinacol ester; 1022092-33-6; (1-(2-Cyanoethyl)-1H-pyrazol-4-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole-1-Propanenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.