Description

2-Chloro-4'-(Trifluoromethyl)-[1,1'-Biphenyl]-4-Amine is a high-value biphenyl derivative featuring both chloro and trifluoromethyl substituents, making it a versatile and critical building block in advanced organic synthesis. Its molecular structure is engineered to serve as a key intermediate in the development of complex molecules, particularly within the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers seeking to incorporate halogenated, fluorinated aromatic systems into new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a key building block for developing novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Used in the development of organic semiconductors, liquid crystals, and advanced polymers due to its rigid biphenyl core and electron-withdrawing substituents.
• Chemical Research & Development: Employed as a standard or reagent in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures for discovery chemistry.
• Dye & Pigment Intermediate: Functions as a starting material for synthesizing specialized dyes and pigments where halogen and fluorine atoms modify color properties and lightfastness.

Basic Information

Product Name	2-Chloro-4'-(Trifluoromethyl)-[1,1'-Biphenyl]-4-Amine
CAS No.	1021580-60-8
Molecular Formula	C13H9ClF3N
Molecular Weight	271.66 g/mol
Synonyms	4-Amino-2-chloro-4'-(trifluoromethyl)biphenyl; [1,1'-Biphenyl]-4-amine, 2-chloro-4'-(trifluoromethyl)-; 2-Chloro-4'-(trifluoromethyl)biphenyl-4-amine; 4'-Trifluoromethyl-2-chlorobiphenyl-4-ylamine; 2-Chloro-4-(trifluoromethyl)[1,1'-biphenyl]-4-amine
EINECS	Contact for details

Quality Control

Our 2-Chloro-4'-(Trifluoromethyl)-[1,1'-Biphenyl]-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for all critical parameters. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.