Description

n-Isopropyl-4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is a high-purity boronic ester derivative, a critical intermediate in modern synthetic organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing biphenyl or substituted phenyl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and optimization of drug candidates through targeted library synthesis and structure-activity relationship (SAR) studies.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing novel palladium catalyst ligands and other organometallic complexes.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs serving the global life sciences industry.

Basic Information

Item	Detail
Product Name	n-Isopropyl-4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide
CAS No.	1019918-74-1
Molecular Formula	C18H28BNO3
Molecular Weight	317.24 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-isopropyl-4-methylbenzamide; 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(propan-2-yl)benzamide; N-Isopropyl-4-methyl-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 1019918-74-1; Benzamide, N-(1-methylethyl)-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Boronic acid, B-[2-[(1-methylethyl)carbamoyl]-5-methylphenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our n-Isopropyl-4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We are committed to meeting the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, and well-ventilated place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.