Description

3-Methyl-2-(5-Phenyl-2H-1,2,3,4-Tetrazol-2-Yl)Butanoic Acid is a high-value, non-natural amino acid derivative featuring a tetrazole moiety, a critical bioisostere for carboxylic acids and amides in medicinal chemistry. This compound matters for its role as a sophisticated building block in the design and synthesis of novel pharmaceutical candidates, enabling the fine-tuning of pharmacokinetic properties and metabolic stability. Research and development teams in the pharmaceutical, agrochemical, and advanced material sectors need this specialized intermediate to accelerate their discovery pipelines and develop next-generation products.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic diseases and central nervous system (CNS) targets.
• Medicinal Chemistry Building Block: Used as a constrained amino acid analog to introduce the tetrazole pharmacophore, which can enhance binding affinity and improve oral bioavailability in drug candidates.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and plant growth regulators that require specific bioisosteric replacements.
• Peptidomimetics Development: Integral for creating peptide mimics where the tetrazole ring replaces a peptide bond or carboxylic acid group, increasing resistance to enzymatic degradation.
• Material Science Precursor: Can be utilized in the development of specialty polymers and ligands for metal-organic frameworks (MOFs) due to its chelating potential.
• Chemical Biology Probes: Acts as a tool compound for studying enzyme inhibition and receptor-ligand interactions in biochemical assays.

Basic Information

Product Name	3-Methyl-2-(5-Phenyl-2H-1,2,3,4-Tetrazol-2-Yl)Butanoic Acid
CAS No.	1019459-07-4
Molecular Formula	C12H14N4O2
Molecular Weight	246.27 g/mol
Synonyms	2-(5-Phenyl-2H-tetrazol-2-yl)-3-methylbutanoic acid; 3-Methyl-2-(5-phenyl-1H-tetrazol-1-yl)butanoic acid (tautomer); 2-(5-Phenyltetrazol-2-yl)-3-methylbutyric acid; 3-Methyl-2-(5-phenyl-2H-tetrazol-2-yl)butyric acid; 2-(5-Phenyl-1,2,3,4-tetrazol-2-yl)-3-methylbutanoic acid; Tetrazole amino acid derivative; (2R/S)-3-Methyl-2-(5-phenyl-2H-tetrazol-2-yl)butanoic acid (racemic mixture); L- or D- configured synonyms may exist for enantiopure forms.
EINECS	Contact for details

Quality Control

Our production of 3-Methyl-2-(5-Phenyl-2H-1,2,3,4-Tetrazol-2-Yl)Butanoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.