Description

4-[3-(Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazol-1-Yl]Butanoic Acid is a high-value, non-natural amino acid derivative featuring a tetrahydroindazole core and a trifluoromethyl group. This compound is a critical building block in modern pharmaceutical research and development, prized for its ability to modulate the physicochemical properties of drug candidates. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule therapeutics targeting a range of diseases.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to introduce favorable properties like metabolic stability and membrane permeability.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced crop protection agents and pesticides.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	4-[3-(Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazol-1-Yl]Butanoic Acid
CAS No.	1018142-46-5
Molecular Formula	C₁₂H₁₅F₃N₂O₂
Molecular Weight	276.25 g/mol
Synonyms	4-(3-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)butanoic acid; 1H-Indazole-1-butanoic acid, 4,5,6,7-tetrahydro-3-(trifluoromethyl)-; 3-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole-1-butanoic acid; 4-(3-Trifluoromethyl-4,5,6,7-tetrahydroindazol-1-yl)butyric acid; Butanoic acid, 4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-; CAS 1018142-46-5
EINECS	Contact for details

Quality Control

Every batch of 4-[3-(Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazol-1-Yl]Butanoic Acid is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency that meet the exacting standards of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.