Description

3-(Aminosulfonyl)-5-Chlorothiophene-2-Carboxylic Acid is a high-purity, multi-functional heterocyclic building block of significant commercial and research interest. Its molecular structure, featuring both a carboxylic acid and a sulfonamide group on a chlorinated thiophene core, makes it a versatile intermediate for synthesizing complex molecules. This compound is primarily sought after by pharmaceutical and agrochemical R&D departments for the development of new active ingredients. Its reliable quality and consistent supply are critical for accelerating discovery pipelines and process scale-up.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in areas requiring sulfonamide or thiophene pharmacophores.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, leveraging its bioactive heterocyclic structure.
• Material Science Research: Serves as a precursor for functionalized polymers or organic electronic materials due to its conjugated thiophene system.
• Chemical Biology & Proteomics: Employed as a building block for designing activity-based probes or enzyme inhibitors targeting sulfonamide-binding proteins.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for clients.
• Academic & Institutional Research: Used in university and government labs for fundamental studies in organic chemistry and medicinal chemistry.

Basic Information

Product Name	3-(Aminosulfonyl)-5-Chlorothiophene-2-Carboxylic Acid
CAS No.	1017791-22-8
Molecular Formula	C5H4ClNO4S2
Molecular Weight	241.68 g/mol
Synonyms	5-Chloro-3-sulfamoylthiophene-2-carboxylic acid; 5-Chloro-3-sulfamoyl-2-thiophenecarboxylic acid; 2-Thiophenecarboxylic acid, 5-chloro-3-sulfamoyl-; 3-Sulfamoyl-5-chlorothiophene-2-carboxylic acid; 5-Chloro-3-sulfamoyltiophene-2-carboxylic acid; 1017791-22-8; 3-Aminosulfonyl-5-chlorothiophene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 3-(Aminosulfonyl)-5-Chlorothiophene-2-Carboxylic Acid is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity (HPLC), identity (IR, NMR), and impurity profiles to meet the exacting requirements of our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.