Description

2-Chloro-5-(Difluoromethoxy)Benzyl Bromide is a high-value, multi-functional chemical building block essential for advanced organic synthesis. Its unique structure, featuring both a reactive benzyl bromide group and a difluoromethoxy substituent, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of new drug candidates targeting central nervous system and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays.
• Organic Electronics: Employed in the synthesis of novel organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: The benzyl bromide moiety makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Chemical Research: A versatile reagent for academic and industrial research in medicinal chemistry and material science.

Basic Information

Item	Details
Product Name	2-Chloro-5-(Difluoromethoxy)Benzyl Bromide
CAS No.	1017779-54-2
Molecular Formula	C9H8BrClF2O
Molecular Weight	285.51 g/mol
Synonyms	1-(Bromomethyl)-2-chloro-5-(difluoromethoxy)benzene; (2-Chloro-5-(difluoromethoxy)phenyl)methyl bromide; α-Bromo-2-chloro-5-(difluoromethoxy)toluene; 2-Chloro-α-bromo-5-(difluoromethoxy)toluene; Benzene, 1-(bromomethyl)-2-chloro-5-(difluoromethoxy)-; 5-(Difluoromethoxy)-2-chlorobenzyl bromide
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-(Difluoromethoxy)Benzyl Bromide is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (HPLC/GC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.