Description

2''-Fluoro-4'',6''-Bis(trifluoromethyl)acetophenone is a specialized fluorinated aromatic ketone building block. This compound is valued for its unique electronic and steric properties imparted by the strategically positioned fluorine and trifluoromethyl groups. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors. The molecule serves as a critical intermediate for synthesizing complex bioactive molecules and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, where the fluorine atoms enhance bioavailability and metabolic stability.
• Ligand Synthesis: Precursor for creating sophisticated ligands in catalysis, including those for cross-coupling and asymmetric synthesis.
• Material Science: Intermediate in the production of fluorinated polymers and liquid crystals with enhanced thermal and chemical resistance.
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	2''-Fluoro-4'',6''-Bis(trifluoromethyl)acetophenone
CAS No.	1017778-58-3
Molecular Formula	C11H5F7O
Molecular Weight	286.15 g/mol
Synonyms	1-(2-Fluorophenyl)-3,5-bis(trifluoromethyl)propan-1-one; 2'-Fluoro-3,5-bis(trifluoromethyl)acetophenone; 2-Fluoro-α,α-bis(trifluoromethyl)acetophenone; 1-(2-Fluorophenyl)-3,3,3-trifluoro-2-(trifluoromethyl)propan-1-one; 2-Fluoro-α,α-bis(trifluoromethyl)phenyl methyl ketone
EINECS	Contact for details

Quality Control

Our 2''-Fluoro-4'',6''-Bis(trifluoromethyl)acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable supply for critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.