Description

4'-Chloro-2',6'-Difluoroacetophenone is a high-purity fluorinated acetophenone derivative, a critical building block in advanced organic synthesis. Its precise molecular architecture, featuring strategically placed halogen atoms, makes it an indispensable intermediate for creating complex, high-value molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorinated aromatic core.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and pesticides, where the chloro-difluoro motif can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic materials.
• Ligand and Catalyst Development: Employed in organometallic chemistry to synthesize novel ligands for catalytic systems.
• Fluorine Chemistry Studies: An important reagent for investigating structure-activity relationships and new fluorination methodologies in academic and industrial R&D.
• Fine Chemical Production: Acts as a versatile intermediate for manufacturing other complex fluorinated aromatic compounds.

Basic Information

Product Name	4'-Chloro-2',6'-Difluoroacetophenone
CAS No.	1017777-45-5
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	1-(4-Chloro-2,6-difluorophenyl)ethan-1-one; 4-Chloro-2,6-difluoroacetophenone; 2',6'-Difluoro-4'-chloroacetophenone; 4-Chloro-2,6-difluoroacetophenone; 1-Acetyl-4-chloro-2,6-difluorobenzene; 4-Chloro-2,6-difluorophenyl methyl ketone; p-Chloro-2,6-difluoroacetophenone
EINECS	Contact for details

Quality Control

Our 4'-Chloro-2',6'-Difluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for all shipments, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.