Description

3'-Fluoro-2'-(trifluoromethyl)acetophenone, 97% is a high-purity fluorinated aromatic ketone building block. This compound is valued for its unique trifluoromethyl and fluorine substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Chemical Biology Probes: Employed in the synthesis of fluorinated probes and tags for imaging and diagnostic applications.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl systems.
• Fluorine Chemistry Library Building: An essential component for creating diverse compound libraries focused on fluorine-containing molecules for high-throughput screening.

Basic Information

Product Name	3'-Fluoro-2'-(trifluoromethyl)acetophenone, 97%
CAS No.	1017777-34-2
Molecular Formula	C9H5F4O
Molecular Weight	204.13 g/mol
Synonyms	1-[3-Fluoro-2-(trifluoromethyl)phenyl]ethan-1-one; 3'-Fluoro-2'-(trifluoromethyl)acetophenone; 3-Fluoro-2-(trifluoromethyl)acetophenone; 1-(3-Fluoro-2-(trifluoromethyl)phenyl)ethanone; 2'-Trifluoromethyl-3'-fluoroacetophenone; α,α,α-Trifluoro-3-fluoro-o-methylacetophenone; 3-Fluoro-α,α,α-trifluoro-o-tolyl methyl ketone
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-2'-(trifluoromethyl)acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure it meets the specified 97% purity grade and is free from critical impurities. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and sources of ignition. Due to its fluoride/strong alkali reactivity profile, ensure segregation from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.