Description

1-Acetyl-4-Pyrrolidin-1-Ylpiperidine-4-Carbonitrile (Saltdata: Free) is a high-purity, advanced pharmaceutical intermediate featuring a unique piperidine-pyrrolidine scaffold. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. Pharmaceutical manufacturers and R&D organizations need it to develop novel therapeutic candidates with high structural precision and reliable batch-to-batch consistency.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• API Development: Serves as a crucial precursor in the research and process development of complex Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile piperidine-pyrrolidine core.
• Preclinical & Clinical Trial Material: Supplied under controlled conditions for the production of materials required for regulatory studies.
• Contract Research & Manufacturing (CRO/CMO): A valuable building block for custom synthesis and scale-up projects in outsourced development.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for target identification and validation in biological systems.

Basic Information

Product Name	1-Acetyl-4-Pyrrolidin-1-Ylpiperidine-4-Carbonitrile (Saltdata: Free)
CAS No.	1017468-05-1
Molecular Formula	C12H19N3O
Molecular Weight	221.30 g/mol
Synonyms	1-[4-(1-Pyrrolidinyl)-4-cyanopiperidin-1-yl]ethanone; 1-Acetyl-4-(1-pyrrolidinyl)-4-piperidinecarbonitrile; 4-(1-Pyrrolidinyl)-1-(acetyl)piperidine-4-carbonitrile; 4-Cyano-4-(pyrrolidin-1-yl)piperidin-1-yl ethanone; 1-Acetyl-4-(pyrrolidin-1-yl)piperidine-4-carbonitrile; 4-(Pyrrolidin-1-yl)-1-acetylpiperidine-4-carbonitrile; 1-Acetyl-4-pyrrolidin-1-ylpiperidine-4-carbonitrile
EINECS	Contact for details

Quality Control

Our 1-Acetyl-4-Pyrrolidin-1-Ylpiperidine-4-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and conformity to client specifications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for prolonged operations to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.