Description

3-Benzyloxy-4-Iodo-5-Nitro-Benzaldehyde is a versatile and highly functionalized aromatic aldehyde building block. Its unique structure, featuring benzyl ether protection, an iodine substituent, and a nitro group, makes it a critical intermediate for advanced organic synthesis. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in medicinal chemistry and material science applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting various disease pathways.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its reactive aldehyde and halogen sites.
• Material Science Research: Serves as a precursor for functionalized organic materials, liquid crystals, and polymers where specific electronic properties are desired.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Chemical Derivatization: The aldehyde group is readily available for condensation reactions (e.g., formation of imines, oximes, hydrazones) to introduce diverse functionality.
• Academic & Contract Research: Essential reagent in university and CRO laboratories for methodological development and exploring new synthetic routes.

Basic Information

Product Name	3-Benzyloxy-4-Iodo-5-Nitro-Benzaldehyde
CAS No.	1016976-13-8
Molecular Formula	C14H10INO4
Molecular Weight	383.14 g/mol
Synonyms	4-Iodo-3-(phenylmethoxy)-5-nitrobenzaldehyde; 3-(Benzyloxy)-4-iodo-5-nitrobenzaldehyde; 5-Nitro-3-benzyloxy-4-iodobenzaldehyde; Benzaldehyde, 3-(benzyloxy)-4-iodo-5-nitro-; 1016976-13-8; 4-Iodo-5-nitro-3-(phenylmethoxy)benzaldehyde
EINECS	Contact for details

Quality Control

Our 3-Benzyloxy-4-Iodo-5-Nitro-Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data from techniques including HPLC, NMR, and IR spectroscopy. Our quality commitment ensures the material meets the exacting standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage or after opening. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.