Description

4,4,5,5-Tetramethyl-2-(4-(Methylsulfinyl)Phenyl)-1,3,2-Dioxaborolane is a high-value organoboron building block featuring a sulfoxide functional group, making it a versatile intermediate for modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, which are fundamental to pharmaceutical and advanced materials research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require high-purity, functionalized boronic esters for Suzuki-Miyaura coupling and other catalytic transformations.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing aryl-sulfoxide motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aryl-boronate functionality.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel chiral ligands and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized for labeling and modifying biomolecules in proteomics and diagnostic assay development.
• Academic & Industrial R&D: A critical reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(4-(Methylsulfinyl)Phenyl)-1,3,2-Dioxaborolane
CAS No.	1016641-70-5
Molecular Formula	C13H19BO3S
Molecular Weight	266.17 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl methyl sulfoxide; (4-(Methylsulfinyl)phenyl)boronic acid pinacol ester; 2-(4-Methylsulfinylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(Methylsulfinyl)benzeneboronic acid pinacol ester; p-(Methylsulfinyl)phenylboronic acid pinacol ester; CAS 1016641-70-5; B-(4-(Methylsulfinyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(4-(Methylsulfinyl)Phenyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.