Description

2-(Pyrrolidin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry, specifically designed for Suzuki-Miyaura cross-coupling reactions. Its core value lies in enabling the efficient and selective construction of complex heterocyclic scaffolds, which are critical in pharmaceutical and agrochemical discovery. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules. CAS No. 1015242-07-5.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) targeting various therapeutic areas, including central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the discovery and development of novel herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Facilitates the creation of organic electronic materials, such as those used in OLEDs and organic photovoltaics, through precise molecular engineering.
• Chemical Biology & Probe Development: Enables the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Library Synthesis for Drug Discovery: A crucial reagent in parallel and combinatorial chemistry for generating diverse compound libraries for high-throughput screening.
• Process Chemistry & Scale-up: Serves as a reliable coupling partner in the development of robust, scalable synthetic routes for commercial manufacturing.

Basic Information

Product Name	2-(Pyrrolidin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	1015242-07-5
Molecular Formula	C14H22BN3O2
Molecular Weight	275.16 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(1-pyrrolidinyl)pyrimidine; 2-(Pyrrolidin-1-yl)pyrimidine-5-boronic acid pinacol ester; 2-Pyrrolidin-1-ylpyrimidine-5-boronic acid pinacol ester; 2-(1-Pyrrolidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; Pyrimidine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(1-pyrrolidinyl)-; 1015242-07-5; 2-Pyrrolidin-1-yl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
EINECS	Contact for details

Quality Control

Our 2-(Pyrrolidin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for critical cross-coupling applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.