Description

2-(Homopiperidin-1-yl)pyrimidine-5-boronic acid pinacol ester is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in the discovery and development of novel active compounds.

Application

• Pharmaceutical Intermediate: A key synthon for constructing pyrimidine-based scaffolds in drug discovery programs, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate heterocyclic systems.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and bioconjugates for studying biological pathways and target engagement.
• Catalyst & Ligand Development: Useful in the preparation of novel bidentate ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex, bespoke organic molecules.

Basic Information

Product Name	2-(Homopiperidin-1-yl)pyrimidine-5-boronic acid pinacol ester
CAS No.	1015242-05-3
Molecular Formula	C15H24BN3O2
Molecular Weight	289.18 g/mol
Synonyms	2-(Hexahydro-1H-azepin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(1-azepanyl)pyrimidine; 2-(Homopiperidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-(1-Azepanyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-(Hexamethyleneimin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; Boronic acid, B-[2-(hexahydro-1H-azepin-1-yl)-5-pyrimidinyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(Homopiperidin-1-yl)pyrimidine-5-boronic acid pinacol ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.