Description

n-(2-Hydroxyethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenesulfonamide is a high-value organoboron building block, specifically a sulfonamide-protected aryl boronic ester. This compound matters for its role as a key synthetic intermediate in modern cross-coupling reactions, enabling the precise construction of complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A critical precursor for introducing the benzenesulfonamide moiety into biaryl structures, a common pharmacophore.
• Pharmaceutical Intermediate: Used in the synthesis of potential drug candidates, particularly those targeting enzymes where the sulfonamide group acts as a binding motif.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, and insecticides that require specific aryl-sulfonamide functionalities.
• Material Science: Exploration into organic electronic materials, such as semiconductors or ligands for metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Can be utilized in the development of activity-based probes or affinity tags due to the reactive boronic ester and the stable sulfonamide linker.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for client-specific custom synthesis projects requiring this specialized boronic ester.

Basic Information

Product Name	n-(2-Hydroxyethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenesulfonamide
CAS No.	1014613-40-1
Molecular Formula	C14H22BNO5S
Molecular Weight	327.21 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2-hydroxyethyl)benzenesulfonamide; 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]sulfonamido]ethanol; N-(2-Hydroxyethyl)-4-(pinacolatoboryl)benzenesulfonamide; 4-Pinacolatoboryl-N-(2-hydroxyethyl)benzenesulfonamide; 1014613-40-1; Aryl Boronic Ester Sulfonamide; Boric acid, B-[4-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our n-(2-Hydroxyethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenesulfonamide is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.