Description

1H-Pyrrolo[2,3-B]Pyridine, 2-Methyl-1-(Phenylsulfonyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in its boronic ester functional group, which enables critical carbon-carbon bond-forming reactions like the Suzuki-Miyaura cross-coupling. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating complex heterocyclic scaffolds found in active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the efficient construction of biaryl and heterobiaryl structures central to medicinal chemistry.
• Agrochemical Research: Used in developing new active ingredients with complex molecular architectures.
• Material Science: Serves as a precursor for organic electronic materials and functional polymers.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and enzyme inhibitors for biological studies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for bespoke chemical synthesis services.

Basic Information

Item	Detail
Product Name	1H-Pyrrolo[2,3-B]Pyridine, 2-Methyl-1-(Phenylsulfonyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1014613-31-0
Molecular Formula	C20H23BN2O4S
Molecular Weight	398.28 g/mol
Synonyms	2-Methyl-1-(phenylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-(phenylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-Methyl-1-tosyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-azaindole (common name); 7-Azaindole boronic ester pinacol ester; 1-(Phenylsulfonyl)-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen) to prevent oxidation and ensure long-term stability. The container should be kept in a dry, well-ventilated area. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.