Description

(4S)-4-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Pentanoic Acid is a high-purity, chiral amino acid derivative featuring a fluorenylmethoxycarbonyl (Fmoc) protecting group on the amine functionality. This compound is critically important as a sophisticated building block in the synthesis of complex peptides and peptidomimetics, where stereochemical integrity is paramount. It is primarily needed by research institutions and pharmaceutical companies engaged in advanced drug discovery, process development, and the production of therapeutic peptides.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the sequential assembly of peptides, ensuring high coupling efficiency and optical purity.
• Pharmaceutical Intermediates: Serves as a critical chiral intermediate in the synthesis of active pharmaceutical ingredients (APIs) for metabolic, oncological, and neurological therapies.
• Peptidomimetic Research: Used to introduce specific side-chain functionalities and stereocenters in the design of non-peptide compounds that mimic peptide bioactivity.
• Bioconjugation & Labeling: The carboxylic acid group allows for conjugation to other molecules, carriers, or surfaces for diagnostic and biochemical applications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery campaigns.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic synthesis and peptide chemistry.

Basic Information

Product Name	(4S)-4-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Pentanoic Acid
CAS No.	1014018-33-7
Molecular Formula	C20H21NO4
Molecular Weight	339.39 g/mol
Synonyms	Fmoc-D-homoallylglycine-OH; Fmoc-D-Hag-OH; (S)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid; (4S)-4-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]pentanoic acid; Fmoc-D-2-aminohex-5-enoic acid; Fmoc-D-homoallylglycine; D-Fmoc-homoallylglycine
EINECS	Contact for details

Quality Control

Our (4S)-4-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Pentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and comprehensive identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.