Description

1-(2-(Methoxymethoxy)Ethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value, protected boronic ester derivative of pyrazole, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing new active ingredients, particularly for creating novel heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing pyrazole and biaryl motifs for oncology, CNS, and metabolic disease targets.
• Agrochemical Synthesis: Building block for developing new generation herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Research: Used in the creation of organic electronic materials, ligands for catalysis, and novel polymers requiring specific boronate functionalization.
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester group is designed for efficient palladium-catalyzed coupling with aryl/heteroaryl halides, enabling library synthesis for drug discovery.
• Chemical Biology & Probe Development: Utilized in synthesizing molecular probes and bioconjugates for studying biological pathways and target engagement.

Basic Information

Product Name	1-(2-(Methoxymethoxy)Ethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1013101-73-9
Molecular Formula	C13H23BN2O4
Molecular Weight	282.15 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[2-(methoxymethoxy)ethyl]-1H-pyrazole; 1H-Pyrazole, 1-[2-(methoxymethoxy)ethyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1-(2-Methoxymethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 1-(2-(Methoxymethoxy)ethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; MME-Protected Pyrazole Boronic Ester Pinacol Ester; Pyrazole Boronate MME Derivative; CAS 1013101-73-9
EINECS	Contact for details

Quality Control

Our 1-(2-(Methoxymethoxy)Ethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting our commitment to supply reliability and technical excellence for your development and scale-up needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) in a freezer (-20°C) to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.