Description

(2R)-2-[(S)-[(4-Fluorophenyl)Amino][4-(Phenylmethoxy)Phenyl]Methyl]Pentanedioic Acid is a high-purity, non-racemic chiral compound of significant interest in advanced pharmaceutical research and development. This molecule serves as a critical synthetic intermediate or potential active pharmaceutical ingredient (API) precursor, valued for its defined stereochemistry and complex molecular architecture. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries working on novel therapeutic agents, particularly in areas requiring sophisticated chiral building blocks.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) targeting central nervous system (CNS) disorders, metabolic diseases, or inflammatory conditions.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale production for new drug candidates under development.
• Asymmetric Synthesis: Serves as a sophisticated substrate or reagent in stereoselective chemical transformations to create other complex chiral molecules.
• Reference Standard: Employed as a high-purity analytical standard for method development, validation, and quality control in regulatory filings.
• Medicinal Chemistry Research: Integral component in structure-activity relationship (SAR) studies and lead optimization programs within drug discovery.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	(2R)-2-[(S)-[(4-Fluorophenyl)Amino][4-(Phenylmethoxy)Phenyl]Methyl]Pentanedioic Acid
CAS No.	1013025-04-1
Molecular Formula	C25H24FNO5
Molecular Weight	437.46 g/mol
Synonyms	(2R)-2-[(S)-[(4-Fluorophenyl)Amino][4-(Phenylmethoxy)Phenyl]Methyl]Pentanedioic Acid; (2R,αS)-α-[[(4-Fluorophenyl)Amino][4-(Benzyloxy)Phenyl]Methyl]Glutaric Acid; (2R)-2-[(S)-[(4-Fluorophenyl)Amino][4-(Benzyloxy)Phenyl]Methyl]Glutaric Acid; (2R)-2-[(S)-[(4-Fluorophenyl)Amino][4-(Benzyloxy)Phenyl]Methyl]Pentanedioic Acid; 1013025-04-1; UNII-7H9F8Q5I8F; 7H9F8Q5I8F
EINECS	Contact for details

Quality Control

Every batch of (2R)-2-[(S)-[(4-Fluorophenyl)Amino][4-(Phenylmethoxy)Phenyl]Methyl]Pentanedioic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are developed to meet the stringent requirements of pharmaceutical R&D and are supported by a detailed Certificate of Analysis (COA) for each lot, which includes chiral purity, assay, and impurity profile data. We adhere to cGMP principles where applicable for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.