Description

2-Fluoro-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenamine is a high-value, multi-functional boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery, ligand synthesis, and the development of functional organic molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl or heterobiaryl structures.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific fluorinated and boronate-functionalized scaffolds.
• Material Science: Building block for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors).
• Chemical Biology & Proteomics: Employed in the development of molecular probes, enzyme inhibitors, and bioconjugation reagents due to its reactive boronate group.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CROs (Contract Research Organizations) serving the global life sciences industry.

Basic Information

Product Name	2-Fluoro-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenamine
CAS No.	1012880-11-3
Molecular Formula	C13H19BFNO2
Molecular Weight	251.11 g/mol
Synonyms	5-Amino-2-fluoro-4-methylphenylboronic acid pinacol ester; (5-Amino-2-fluoro-4-methylphenyl)boronic acid pinacol ester; 2-Fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-4-methylbenzenamine; 1012880-11-3; Boronic acid, B-(5-amino-2-fluoro-4-methylphenyl)-, 1,1-dimethylethyl ester; AN-329/25034085
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenamine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by NMR)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.