Description

n-Ethyl-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Ethanamine is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries seeking to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing biaryl or aryl-heteroaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: The protected boronic ester group acts as a stable, air-tolerant handle for palladium-catalyzed carbon-carbon bond formation under mild conditions.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides that require specific aromatic architectures.
• Organic Light-Emitting Diode (OLED) Materials: Employed in the synthesis of electron-transport or host materials for display and lighting technologies.
• Ligand and Catalyst Development: The amine functionality allows for further derivatization to create novel ligands for catalysis or metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for creating tagged molecules or PROTACs (Proteolysis Targeting Chimeras) for target identification and validation.

Basic Information

Product Name	n-Ethyl-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Ethanamine
CAS No.	1012785-44-2
Molecular Formula	C19H32BNO2
Molecular Weight	317.28 g/mol
Synonyms	N-Ethyl-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]ethanamine; 4-[(Diethylamino)methyl]phenylboronic acid pinacol ester; [4-(Diethylaminomethyl)phenyl]boronic acid pinacol ester; 2-[4-[(Diethylamino)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Diethyl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-amine; B-[4-[(Diethylamino)methyl]phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our n-Ethyl-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Ethanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.